CUB domain-containing protein 1; membrane glycoprotein gp140; subtractive immunization M plus HEp3-associated 135 kD protein; SIMA135; transmembrane & associated with src kinases; CD318 (CDCP1, TRASK, UNQ2486/PRO5773)

Function

• cell adhesion
• cell matrix association
• tumor progression & metastasis
• interacts with N-cadherin, P-cadherin, syndecan-1, syndecan-4, serine protease ST14, SRC, protein kinase C gamma
• phosphorylated on Tyr by SRC, YES, protein kinase C gamma, suramin; phosphorylated in response to dissociation of integrin alpha-6, beta-4 from laminin-5

Compartment

• cell membrane
• shedding may lead to a soluble peptide

Alternative splicing

named isoforms=3

Expression

• highly expressed in mitotic cells
• low expression during interphase
• expressed in skeletal muscle, colon > kidney, small intestine, placenta, lung
• expressed in human tumor cell lines, colorectal cancer, breast carcinoma, lung cancer

More general terms

• CD antigen
• glycoprotein
• phosphoprotein
• CUB domain-containing protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64866
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64866
• OMIM: https://mirror.omim.org/entry/611735
• UniProt: http://www.uniprot.org/uniprot/Q9H5V8.html