CD49f (integrin alpha-6, integrin alpha-F, ITGA6)
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Function
- associates with integrin beta-1 (integrin alpha-6/beta-1)
- associates with integrin beta-4 (integrin alpha-6/beta-4)
- interacts with HPS5
- isoforms containing segment A, but not segment B, are major targets for PMA-induced phosphorylation
- phosphorylation occurs on Ser-1103 of isoform alpha-6X1X2A
- phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand
Structure
- composed of an heavy & a light chain linked by a disulfide bond
- belongs to the integrin alpha chain family
- contains 7 FG-GAP repeats
Compartment
- membrane; single-pass type 1 membrane protein
Alternative splicing
- named isoforms=6
- additional isoforms seem to exist
- at least four alternatively spliced domains, two extracellular (X1 & X2) & two cytoplasmic (A & B)
- isoform alpha-6X1A, isoform alpha-6X1B & isoform alpha-6X1X2A (minor) have been detected
Expression
- isoforms containing segment X1 are ubiquitously expressed
- isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts & myotubes, & in a limited number of cell lines; always coexpressed with the ubiquitous isoform containing segment X1
- in some tissues (e.g. salivary gland), isoforms containing cytoplasmic segment A & isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis & segment B in kidney)
Pathology
- defects in ITGA6 are a cause of epidermolysis bullosa with pyloric atresia