ATP-dependent RNA helicase DDX3X; DEAD box protein 3, X-chromosomal; helicase-like protein 2; HLP2; DEAD box, X isoform (DDX3X, DBX, DDX3)

Function

• ATP-dependent RNA helicase
• identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP & YBX1
• found in a complex with Rev & XPO1
• interacts with XPO1 & TDRD3
• interacts with HCV core protein

Structure

• belongs to the DEAD box helicase family, DDX3/DED1 subfamily
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain

Compartment

• nuclear speckle
• cytoplasm
• located predominantly in nuclear speckles &, at low levels, throughout the cytoplasm
• located to the outer side of nuclear pore complexes
• shuttles between the nucleus & cytoplasm (XPO1-dependent)

Pathology

• acts as a cofactor for XPO1- mediated nuclear export of incompletely spliced HIV-1 Rev RNAs
• also involved in HIV-1 replication
• interacts specifically with hepatitis C virus core protein resulting in a change in intracellular location

More general terms

• DEAD box ATP-dependent helicase
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1654
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1654
• OMIM: https://mirror.omim.org/entry/300160
• UniProt: http://www.uniprot.org/uniprot/O00571.html