double-stranded RNA-binding protein Staufen homolog 1 (STAU1, STAU)

Function

• binds double-stranded RNA (sequence-independent) & tubulin
• specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal & RNA components, & in stimulating their translation at the site
• binds with low affinity single-stranded RNA or DNA homopolymers
• interacts with CASC3 (RNA-dependent)
• one of the DRDB could be involved in rER binding
• C-terminal contains the tubulin binding domain

Compartment

• endoplasmic reticulum
• localizes exclusively with the rough reticulum endoplasmic (rER)

Alternative splicing

named isoforms=2

Expression

• widely expressed
• expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney, placenta

Pathology

• interacts with influenza virus nonstructural protein NS

More general terms

• RNA-binding protein

Database

• OMIM: https://mirror.omim.org/entry/601716
• UniProt: http://www.uniprot.org/uniprot/O95793.html