protein CASC3; cancer susceptibility candidate gene 3 protein; metastatic lymph node gene 51 protein; MLN 51; protein barentsz; Btz (CASC3 MLN51)

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Function

component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs
stimulates the ATPase & RNA-helicase activities of EIF4A3
plays a role in the stress response by participating in cytoplasmic stress granules assembly & by favouring cell recovery following stress
component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons (putative)
may play a role in mRNA transport
binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions
binds poly(G) & poly(U) RNA homopolymer
forms homooligomers (putative)
interacts with STAU (RNA-dependent)
part of the exon junction complex core complex
interacts with EIF4A3, MAGOH, NXF1 & RBM8A

cytoplasm, perinuclear region
nucleus, nuclear speckle
predominantly found in the perinuclear region (putative)
shuttles between the nucleus & the cytoplasm in a CRM1-dependent manner
travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA
shuttles between the cytoplasm & the stress granules
found in nuclear speckles
colocalizes in nuclear speckles with MAGOH
under stress condition, colocalizes with FMR1 & TIA1, but not MAGOH & RBM8A EJC core factors, in cytoplasmic stress granules, which contain stored mRNAs whose translation is stopped in response to stress