nucleolysin TIA-1 isoform p40; p40-TIA-1; RNA-binding protein TIA-1; contains: nucleolysin TIA-1 isoform p15; p15-TIA-1 (TIA1)

Function

• RNA-binding protein
• possesses nucleolytic activity against cytotoxic lymphocyte target cells
• may be involved in apoptosis
• TIA-1 major granule-associated species is a 15-kDa protein (p15-TIA-1) that seems to be derived by proteolytic processing from the C-terminus of p40-TIA-1

Structure

contains 3 RRM domain (RNA recognition motif)s

Compartment

• cytoplasmic granule
• cytoplasmic granules of cytolytic T-lymphocytes

Alternative splicing

named isoforms=2; long, short

More general terms

• RNA-binding protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P31483.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7072
• OMIM: https://mirror.omim.org/entry/603518