RNA-binding protein 8A; RNA-binding motif protein 8A; ribonucleoprotein RBM8A; RNA-binding protein Y14; binder of OVCA1-1; BOV-1 (RBM8A, RBM8, HSPC114, MDS014)

Function

• component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs
• heterodimer with MAGOH
  • component of the nonsense mediated decay (NMD) pathway
  • interacts with PYM to enhance translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex
• found in a post-splicing complex with NXF1, RBM8A, RENT1, RENT2, RENT3A, RENT3B & RNPS1
• interacts with BAT1, MAGOH, OVCA1, RENT3B, RNPS1, SRRM1 & THOC4
• identified in the spliceosome C complex
• interacts with WIBG/PYM; the interaction is direct
• leads to dissociate the EJC from spliced mRNAs
• associates with polysomes

Structure

• belongs to the RBM8A family
• contains 1 RRM domain (RNA recognition motif)

Compartment

• nucleus, nuclear speckle, cytoplasm
• nucleocytoplasmic shuttling protein
• travels to the cytoplasm as part of the exon junction complex bound to mRNA
• colocalizes with the core exon junction complex, THOC4, NXF1 & UAP56 in the nucleus & nuclear speckles

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• nuclear protein
• RNA-binding motif protein
• phosphoprotein

Component of

• exon junction complex (EJC)
• spliceosome C complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9939
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9939
• OMIM: https://mirror.omim.org/entry/605313
• UniProt: http://www.uniprot.org/uniprot/Q9Y5S9.html