regulator of nonsense transcripts 2 (nonsense mRNA reducing factor 2, up-frameshift suppressor 2 homolog, hUpf2, UPF2, KIAA1408, RENT2)

Function

• part of a post-splicing multiprotein complex
• involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons
• binds spliced mRNA
• interacts with RENT1, RENT3, RENT3B, EIF4A1, SUI1

Structure

contains 3 MIF4G domains

Compartment

cytoplasm, perinuclear region

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• regulator of nonsense transcripts

Component of

• mRNA decay complex
• post-splicing multiprotein complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2601
• OMIM: https://mirror.omim.org/entry/605529
• UniProt: http://www.uniprot.org/uniprot/Q9HAU5.html