regulator of nonsense transcripts 1 (nonsense mRNA reducing factor 1, NORF1, up-frameshift suppressor 1 homolog, hUpf1, RENT1, KIAA0221, UPF1)

Function

• part of a post-splicing multiprotein complex
• involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons
• essential for embryonic viability

Structure

• the [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family
• belongs to the DNA2/NAM7 helicase family

Compartment

cytoplasmic

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• regulator of nonsense transcripts
• phosphoprotein

Component of

• mRNA decay complex
• post-splicing multiprotein complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5976
• OMIM: https://mirror.omim.org/entry/601430
• UniProt: http://www.uniprot.org/uniprot/Q92900.html