regulator of nonsense transcripts 3B (nonsense mRNA reducing factor 3B, up-frameshift suppressor homolog 3B, hUpf3B, hUpf3p-X, UPF3B, RENT3B, UPF3X)

Function

• part of a post-splicing multiprotein complex with NXF1, RBM8A, RENT1, RENT2, RENT3A, RENT3B & RNPS
• found in a complex with SMG1, RENT1, RENT2 & RENT3B
• found in a mRNP complex with RENT3A, RENT3B, RBM8A, THOC4 & NXF1
• found in a mRNA decay complex with EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, DCP2, RENT1, RENT2 & RENT3B
• involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons
• binds spliced mRNA upstream of exon-exon junctions
• interacts with EST1A, RENT2 & RBM8A

Compartment

• nucleus, cytoplasm
• shuttles between the nucleus & cytoplasm

Alternative splicing

named isoforms=2

Expression

• expressed in testis, uterus, prostate, heart, muscle, brain, spinal cord & placenta

Pathology

• defects in UPF3B are the cause of X-linked syndromic mental retardation type 14 (MRXS14)

More general terms

• regulator of nonsense transcripts

Component of

• mRNA decay complex
• post-splicing multiprotein complex
• exon junction complex (EJC)

Database

• OMIM: https://mirror.omim.org/entry/300298
• UniProt: http://www.uniprot.org/uniprot/Q9BZI7.html