5'-3' exoribonuclease 1; strand-exchange protein 1 homolog (XRN1, SEP1)

Function

• major 5'-3' exoribonuclease involved in mRNA decay
• binds to RNA & DNA
• may act as tumor suppressor in osteogenic sarcoma
• associates with alpha & beta tubulins
• component of mRNA decay complex

Compartment

• cytoplasm
• discrete foci inner surface of cell membrane.

Expression

• expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma
• induction by GDNF

More general terms

• exoribonuclease

Component of

• mRNA decay complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54464
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54464
• OMIM: https://mirror.omim.org/entry/607994
• UniProt: http://www.uniprot.org/uniprot/Q8IZH2.html