serine/threonine protein kinase SMG1; SMG-1; hSMG-1; 61E3.4; lambda/iota protein kinase C-interacting protein; lambda-interacting protein (SMG1, ATX, KIAA0421, LIP)
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Function
- serine/threonine kinase
- mRNA surveillance
- genotoxic stress response
- recognizes the substrate consensus sequence [ST]-Q
- nonsense-mediated decay (NMD) of mRNAs containing premature stop codons via phosphorylation of UPF1
- phosphorylates p53
- depletion leads to spontaneous DNA damage & increased sensitivity to ionizing radiation
- component of a post-splicing multiprotein NMD complex with UPF1, UPF2, EST1A, EST1B, UPF3
- component of SMG1C complex
- autophosphorylated
- inhibited by caffeine, LY294002, wortmannin
Structure
- belongs to the PI3/PI4-kinase family
- contains 1 FAT domain
- contains 1 FATC domain
- contains 1 HEAT repeat
- contains 1 PI3K/PI4K domain
Compartment
Alternative splicing
named isoforms=4
Expression
- widely expressed
- expressed in heart, skeletal muscle > placenta, brain, lung, spleen > liver
Genetics
- gene is located in a region of chromosome 16 that contains 2 segmental duplications