SMG1C complex

Function

• role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons
• recruited by release factors to stalled ribosomes
• recruitment of SMG8 to SMG1 N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain
• SMG8 heterodimers with SMG9 may represent a SMG1C intermediate form

Structure

• subunits include: SMG1, SMG8 & SMG9

More general terms

• molecular complex