protein SMG8; amplified in breast cancer gene 2 protein; protein smg-8 homolog (SMG8 ABC2 C17orf71)

Function

• role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons
• recruited by release factors to stalled ribosomes together with SMG1 & SMG9 (forming the SMG1C protein kinase complex)
  • in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex & to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC)
• acts as a regulator of kinase activity
• phosphorylated by SMG1
• component of the SMG1C complex

Structure

belongs to the SMG8 family

Alternative splicing

named isoforms=3

More general terms

• phosphoprotein

Component of

• SMG1C complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55181
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55181
• OMIM: https://mirror.omim.org/entry/613175
• UniProt: http://www.uniprot.org/uniprot/Q8ND04.html