protein SMG9; protein smg-9 homolog (SMG9, C19orf61)

Function

• role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons
• recruited by release factors to stalled ribosomes together with SMG1 & SMG8 (forming the SMG1C protein kinase complex)
• in the SMG1C complex, is required for efficient association between SMG1 & SMG8
• phosphorylated by SMG1
• component of the SMG1C comple

Structure

belongs to the SMG9 family

Alternative splicing

named isoforms=2

More general terms

• phosphoprotein

Component of

• SMG1C complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56006
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56006
• OMIM: https://mirror.omim.org/entry/613176
• UniProt: http://www.uniprot.org/uniprot/Q9H0W8.html