regulator of nonsense transcripts 3A (nonsense mRNA reducing factor 3A, up-frameshift suppressor homolog 3A, hUpf3, UPF3A, RENT3A, UPF3)

Function

• part of a multiprotein post-splicing mRNP complex
• role in mRNA nuclear export & mRNA surveillance
• role in nonsense-mediated decay mRNAs containing premature stop codons
• binds spliced mRNA upstream of exon-exon junctions

Compartment

• nucleus, cytoplasm
• shuttling between nucleus & cytoplasm

Expression

• isoform 1 expressed in testis, uterus, muscle, fetal brain, spinal cord
• isoform 2 expressed in fetal brain, spinal cord.

More general terms

• regulator of nonsense transcripts
• phosphoprotein

Component of

• post-splicing multiprotein complex
• exon junction complex (EJC)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6511
• OMIM: https://mirror.omim.org/entry/605530
• UniProt: http://www.uniprot.org/uniprot/Q9H1J1.html