protein SMG5 (SMG-5 homolog, EST1-like protein B, LPTS-interacting protein, LPTS-RP1, SMG5, EST1B, KIAA1089)

Function

• role in nonsense-mediated mRNA decay
• promotes dephosphorylation of RENT1
• necessary for TERT activity
• interacts with TERT, PP2AC & SMG1
• component of a complex that contains SMG1, SMG5, SMG7, PP2AC, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) & phosphorylated RENT1
  • not detected in complexes that contain unphosphorylated RENT1
• detected in cytoplasmic mRNA decay bodies

Structure

contains 1 PINc domain

Compartment

• cytoplasm, nucleus
• shuttles between nucleus & cytoplasm

Expression

ubiquitous

More general terms

• other protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9UPR3.html