protein SMG7 (SMG-7 homolog, EST1-like protein C, SMG7, C1orf16, EST1C, KIAA0250)

Function

• role in nonsense-mediated mRNA decay
• recruits RENT1 to cytoplasmic mRNA decay bodies
• part of a complex that contains SMG5, SMG7, PP2AC, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) & phosphorylated RENT1

Structure

contains 2 TPR repeats

Compartment

• cytoplasm, nucleus
• predominantly cytoplasmic, & nuclear
• shuttles between nucleus & cytoplasm

Alternative splicing

named isoforms=4

More general terms

• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q92540.html