mRNA-decapping enzyme 2; hDpc; nucleoside diphosphate-linked moiety X motif 20; Nudix motif 20 (DCP2, NUDT20)

Function

• degradation of mRNAs
  • normal mRNA turnover
  • nonsense-mediated mRNA decay
• removes the 7-methyl guanine cap structure from mRNA, yields 5'-phosphorylated mRNA fragment & 7m-GDP
• higher activity towards mRNAs that lack a polyA tail
• no activity towards a cap structure without RNA
• component of mRNA decay complex
• interacts with DCP1A, DPC1B, RENT1, RENT2 & RENT3B

Cofactor: Mn+2 or Mg+2

Compartment

• associates with polysomes
• predominantly cytoplasmic, discrete foci
• minor amount nuclear

More general terms

• mRNA decapping enzyme
• nucleoside diphosphate-linked moiety X motif

Component of

• mRNA decay complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=167227
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:167227
• OMIM: https://mirror.omim.org/entry/609844
• UniProt: http://www.uniprot.org/uniprot/Q8IU60.html