exosome component 4 (exosome complex exonuclease RRP41, ribosomal RNA processing protein 41, p21A, ski6, EXOSC4)

Function

• component of the exosome 3'->5' exoribonuclease complex
• found in a mRNA decay complex with RENT1, RENT2 & RENT3B
• also associated with the GTPase Ran

Structure

belongs to the Rnase PH family

Compartment

cytoplasm, nucleus, nucleolus

More general terms

• protein subunit
• nuclear protein

Component of

• exosome multienzyme ribonuclease complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5451
• OMIM: https://mirror.omim.org/entry/606491
• UniProt: http://www.uniprot.org/uniprot/Q9NPD3.html