exosome multienzyme ribonuclease complex

Function

• 3'->5' exoribonuclease
• degrades inherently unstable mRNAs containing AU-rich elements within their 3' untranslated regions

Structure

• consists of at least 11 subunits:
  • EXOSC1/CSL4, EXOSC2/RRP4, EXOSC3/RRP40, EXOSC4/RRP41, EXOSC5/RRP46, EXOSC6/MTR3, EXOSC7/RRP42, EXOSC8/RRP43, EXOSC9/Scl-75, DIS3/RRP44, EXOSC10/Scl-100 (only in nuclear complex)

More general terms

• molecular complex
• exoribonuclease

Additional terms

• exosome; ectosome; oncosome