exosome complex exonuclease MTR3 (mRNA transport regulator 3 homolog, hMtr3, exosome component 6, p11, EXOSC6 MTR3)

Function

• component of the exosome multienzyme ribonuclease complex
• required for the 3' processing of the 7S pre-RNA to the mature 5.8S rRNA
• probably has a 3'-5' exonuclease activity
• in the exosome, interacts directly with EXOSC1,EXOSC7 & EXOSC8

Structure

belongs to the RNase PH family

Compartment

cytoplasm, nucleus, nucleolus

More general terms

• exoribonuclease

Component of

• exosome multienzyme ribonuclease complex

Database

• OMIM: https://mirror.omim.org/entry/606490
• UniProt: http://www.uniprot.org/uniprot/Q5RKV6.html