exosome component 1; 3'-5' exoribonuclease CSL4 homolog; CGI-108 (EXOSC1, CSL4)

Function

• component of the exosome 3'->5' exoribonuclease complex
• also associated with the GTPase Ran

Structure

• N- & C-terminal regions of the protein are required for interaction with RRP46
• contains 1 S1 motif domain

Compartment

nucleus, nucleolus

More general terms

• protein subunit
• nuclear protein

Component of

• exosome multienzyme ribonuclease complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5101
• OMIM: https://mirror.omim.org/entry/606493
• UniProt: http://www.uniprot.org/uniprot/Q9Y3B2.html