exosome component 5; exosome complex exonuclease RRP46; ribosomal RNA processing protein 46; p21B (EXOSC5)

Function

• component of the exosome 3'->5' exoribonuclease complex
• also associated with the GTPase Ran
• interacts directly with EXOSC1

Structure

belongs to the Rnase PH family

Compartment

nucleus, nucleolus

Expression

• expressed in testes

Pathology

• highly expressed in a variety of hematopoietic & epithelial tumor cell lines, but not in normal hematopoietic tissues or other normal tissue, with the exception of testis

More general terms

• protein subunit
• nuclear protein
• phosphoprotein

Component of

• exosome multienzyme ribonuclease complex

Database

• OMIM: https://mirror.omim.org/entry/606492
• UniProt: http://www.uniprot.org/uniprot/Q9NQT4.html