exosome complex exonuclease RRP44 (ribosomal RNA processing protein 44, DIS3 protein homolog, DIS3, KIAA1008, RRP44)

Function

• component of the exosome 3'->5' exoribonuclease complex
• also associated with the GTPase Ran

Structure

• belongs to the ribonuclease II (RNB) family
• contains 1 PINc domain

Compartment

cytoplasm, nucleus, nucleolus

Alternative splicing

named isoforms=2

Expression

widely expressed

More general terms

• protein subunit
• nuclear protein

Component of

• exosome multienzyme ribonuclease complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2289
• OMIM: https://mirror.omim.org/entry/607533
• UniProt: http://www.uniprot.org/uniprot/Q9Y2L1.html