non-secretory ribonuclease; ribonuclease US; eosinophil-derived neurotoxin; Rnase UpI-2; ribonuclease 2; Rnase 2 (RNASE2, EDN, RNS2)

Function

• non-secretory ribonuclease
• pyrimidine specific nuclease with a slight preference for U. cytotoxin & helminthotoxin
• selectively chemotactic for dendritic cells
• possesses a wide variety of biological activities
• a particular signal processing & glycosylation pattern may differentiate the UpI2 Rnase, found specifically in pregnant women urine, from other nonsecretory Rnases
• endonucleolytic cleavage to nucleoside 3'-phosphates & 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates

Structure

• N-terminal region is necessary for mediating chemotactic activity
• belongs to the pancreatic ribonuclease family

Compartment

• lysosome (probable)
• cytoplasmic granule
• matrix of eosinophil's large specific granule

Expression

liver, lung, spleen, leukocytes & body fluids

Pathology

• EDN induces ataxia & paralysis, the neurotoxic effect known as the Gordon phenomenon

More general terms

• endoribonuclease
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6036
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6036
• OMIM: https://mirror.omim.org/entry/131410
• UniProt: http://www.uniprot.org/uniprot/P10153.html