THO complex subunit 4; Tho4; Ally of AML-1 & LEF-1; transcriptional coactivator Aly/REF; bZIP-enhancing factor BEF (THOC4, ALY, BEF, ALYREF)

Function

• acts as chaperone
• promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains
• promotes transcriptional activation
• mRNA processing & export
• component of THO/TREX complex recruited to transcribed genes
• travels with RNA polymerase during elongation
• component of exon junction complex
• remains associated with spliced mRNA
• mRNA export & nonsense-mediated RNA decay
• binds LEF1 & RUNX1, NFX1, NXF1, RBM8A
• binds UL54 from Herpes simplex type 1
• component of several complexes involved in mRNA processing & export
  • component of THO/TREX complex
  • component of exon junction complex
  • component of mRNA splicing-dependent exon junction complex

Structure

• homomultimer
• contains 1 RRM domain (RNA recognition motif)

Compartment

• nucleus
• translocates to cytoplasm as part of exon junction complex bound to mRNA

Pathology

• antibodies against THOC4 are found in sera of patients with systemic lupus erythematosus

More general terms

• protein subunit
• chaperonin; chaperone

Component of

• exon junction complex (EJC)
• THO/TREX complex

Database

• OMIM: https://mirror.omim.org/entry/604171
• UniProt: http://www.uniprot.org/uniprot/Q86V81.html