serine/arginine repetitive matrix protein 1; SR-related nuclear matrix protein of 160 kD; SRm160; Ser/Arg-related nuclear matrix protein (SRRM1 SRM160)

Function

• component of pre- & post-splicing multiprotein mRNP complexes
• pre-mRNA processing
• promotes constitutive & exonic splicing enhancer-dependent splicing
• stimulates mRNA 3'-end cleavage
• binds both pre-mRNA & spliced mRNA 20-25 nt upstream of exon-exon junctions
• binds RNA & DNA with low sequence specificity
• component of the active spliceosome
• component of pre-mRNA splicing complex
• component of mRNA splicing-dependent exon junction complex
• identified in the spliceosome C complex
• interacts with BAT1, CPSF1, RBM8A, RNPS1, & THOC4
• seems to be a componnt of RNA export complexes that are released from nuclear speckles (ATP-dependent)

Structure

• belongs to the splicing factor SR family
• contains 1 PWI domain

Compartment

nuclear matrix, nuclear speckle

Alternative splicing

named isoforms=2

More general terms

• nuclear protein
• phosphoprotein

Component of

• exon junction complex (EJC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10250
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10250
• OMIM: https://mirror.omim.org/entry/605975
• UniProt: http://www.uniprot.org/uniprot/Q8IYB3.html