diphthamide biosynthesis protein 1 (DPH1 homolog, HsDph1, diphthamide biosynthesis protein 2 homolog-like 1, DPH2-like 1, diphthamide biosynthesis protein 2-like, DPH-like 1, ovarian cancer-associated gene 1 protein, DPH1, DPH2L, DPH2L1, OVCA1)

Function

• required for the first step in the synthesis of diphthamide
• when overexpressed, suppresses colony formation ability & growth rate of ovarian cancer cells
• tumor suppressor in lung & breast cancers (putative)
• role in embryonic growth, organogenesis & postnatal survival (putative)
• interacts with DPH2 (putative)
• interacts with RBM8A

Structure

belongs to the DPH1/DPH2 family, DPH1 subfamily

Compartment

• nucleus, cytoplasm
• punctate, primarily perinuclear localization

Alternative splicing

named isoforms=3

Expression

• expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis & ovary

Pathology

• diminished expression in primary breast & ovarian tumors

Notes

uncertain whether Met-1 or Met-6 is the initiator

More general terms

• nuclear protein
• anti-oncoprotein (tumor suppressor protein)

Database

• OMIM: https://mirror.omim.org/entry/603527
• UniProt: http://www.uniprot.org/uniprot/Q9BZG8.html