heterogeneous nuclear ribonucleoprotein Q (hnRNP-Q, synaptotagmin-binding cytoplasmic RNA-interacting protein, glycine- & tyrosine-rich RNA-binding protein, GRY-RBP, NS1-associated protein 1, SYNCRIP, HNRPQ, NSAP1)
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Function
- implicated in mRNA processing mechanisms
- translationally coupled mRNA turnover
- component of spliceosome C complex
- domain containing 8 Arg-Gly-Gly repeats may be involved in RNA-binding & protein-protein interactions
- phosphorylated on Tyr in vivo
- membrane-bound form found in microsomes is phosphorylated in vitro by insulin receptor tyrosine kinase (INSR); phosphorylation inhibited upon binding to RNA
- cytoplasmic form is poorly phosphorylated
Structure
- domain containing 8 Arg-Gly-Gly repeats may be involved in RNA-binding & protein-protein interactions
Compartment
- microsome, nucleus
- Tyr phosphorylated form bound to RNA is found in microsomes
Alternative splicing
named isoforms=5
Expression
- ubiquitously expressed
- expressed in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood, testis