double-stranded RNA-binding protein Staufen homolog 2 (STAU2)

Function

• RNA-binding protein
  • DRBM 3 domain major RNA-binding motif
• microtubule-dependent transport of neuronal RNA from perikarya to dendrite
• localization of specific mRNAs to dendrites as prerequisite for neurite outgrowth & plasticity
• interacts with exportin XPO5 via DRBM 3 domain, requires RNA & RAN bound to GTP
• interacts with microtubules
• isoforms 2 & 3 may also interact with ribosomes, independent of translation

Structure

• contains 4 DRBM domains (double-stranded RNA-binding domains)

Compartment

• cytoplasm, nucleus, nucleolus
• shuttles between nucleolus, nucleus & cytoplasm
• nuclear export of isoform 1 is independent of XPO1/CRM1 & requires exportin XPO
• nuclear export of isoform 2 & 3 can occur by both XPO1/CRM1- dependent & XPO1/CRM1-independent pathways
• found in large cytoplasmic ribonucleoprotein (RNP) granules present in the actin rich regions of myelinating processes
• associated with microtubules, polysomes & endoplasmic reticulum
• recruited to stress granules upon inhibition of translation or oxidative stress

Alternative splicing

named isoforms=5

More general terms

• phosphoprotein
• nuclear protein
• RNA-binding protein

Database

• OMIM: https://mirror.omim.org/entry/605920
• UniProt: http://www.uniprot.org/uniprot/Q9NUL3.html