polypyrimidine tract-binding protein 2 (neurally-enriched homolog of PTB, neural polypyrimidine tract-binding protein, PTB-like protein, PTBP2, NPTB, PTB, PTBLP)

Function

• RNA-binding protein
• binds to intronic polypyrimidine tracts & mediates negative regulation of exon splicing
• antagonizes ability of NOVA1 to activate exon selection (tissue-specific)
• role in regulation of translation
• interacts with NOVA1 & NOVA2
• part of a ternary complex containing KHSRP & HNRPH1

Structure

• monomer
• contains 4 RRM domains (RNA recognition motif)

Compartment

nucleus

Alternative splicing

named isoforms=6

Expression

• mainly expressed in brain
• also detected in other tissues, including heart & skeletal muscle
• isoforms 1 & 2 are specifically expressed in neuronal tissues
• isoforms 3 & 4 are expressed in non-neuronal tissues
• isoforms 5 & 6 are truncated forms expressed in non-neuronal tissues

More general terms

• RNA-binding protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/608449
• UniProt: http://www.uniprot.org/uniprot/Q9UKA9.html