far upstream element-binding protein 2; FUSE-binding protein 2; KH type-splicing regulatory protein; KSRP; p75 (KHSRP, FUBP2)

Function

• binds to the dendritic targeting element
• may play a role in mRNA trafficking (putative)
• part of a ternary complex that binds to the downstream control sequence (DCS) of pre-mRNA
• mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing
• may interact with single- stranded DNA from the far-upstream element (FUSE)
• may activate gene expression
• also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE- containing mRNAs
• phosphorylated upon DNA damage, probably by ATM or ATR
• part of a ternary complex containing FUBP2, PTBP1, PTBP2 & HNRPH1
• interacts with PARN

Structure

• belongs to the KHSRP family
• contains 4 KH domains

Compartment

• nucleus (putative), cytoplasm
• a small proportion is also found in the cytoplasm of neuronal cell bodies & dendrites (putative)

Alternative splicing

named isoforms=2

Expression

• detected in neural & non-neural cell lines

More general terms

• Far upstream element binding protein (FUSE binding protein)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8570
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8570
• OMIM: https://mirror.omim.org/entry/603445
• UniProt: http://www.uniprot.org/uniprot/Q92945.html