heterogeneous nuclear ribonucleoprotein H; hnRNP H; contains: heterogeneous nuclear ribonucleoprotein H, N-terminally processed (HNRNPH1, HNRPH, HNRPH1)

Function

• component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm
• mediates pre-mRNA alternative splicing regulation
• inhibits, together with CUGBP1, insulin receptor pre-mRNA exon 11 inclusion in myoblasts
• binds to the insulin receptor RNA
• binds poly(rG)
• part of a ternary complex containing FUBP2, PTBP1, PTBP2 & HNRNPH1
• identified in the spliceosome C complex
• interacts with IGF2BP1
• interacts with CUGBP1 (RNA-dependent)
• interacts with MBNL1 (RNA-independent)

Structure

• each quasi-RRM repeat bound poly(rG); only the N-terminal QRRM bound poly(rC) & poly(rU)
• none of the repeats bound detectable amounts of poly(rA)
• contains 3 RRM domain (RNA recognition motif)s

Compartment

nucleus, nucleoplasm

Expression

• expressed ubiquitously

Pathology

• up-regulated in myotonic dystrophy pathophysiology

More general terms

• heterogeneous nuclear ribonucleoprotein (hnRNP)
• RNA-binding protein
• phosphoprotein

Component of

• spliceosome C complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3187
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3187
• OMIM: https://mirror.omim.org/entry/601035
• UniProt: http://www.uniprot.org/uniprot/P31943.html