polypyrimidine tract-binding protein 1; PTB; heterogeneous nuclear ribonucleoprotein I; hnRNP I; 57 kD RNA-binding protein PPTB-1 (PTBP1, PTB)

Function

• plays a role in pre-mRNA splicing
• binds to the polypyrimidine tract of introns
• may promote the binding of U2 snRNP to pre-mRNA
• cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA
• component of FUBP2/PTBP1/PTBP2/HNRPH1 complex
• interacts with RAVER1 & SFPQ

Structure

• monomer
• contains 4 RRM domain (RNA recognition motif)s

Compartment

nucleus

Alternative splicing

named isoforms=2 comment=additional isoforms seem to exist

More general terms

• nuclear protein
• RNA-binding protein
• phosphoprotein

Component of

• FUBP2/PTBP1/PTBP2/HNRPH1 complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5725
• OMIM: https://mirror.omim.org/entry/600693
• UniProt: http://www.uniprot.org/uniprot/P26599.html