ribonucleoprotein PTB-binding 1 (protein raver-1, RAVER1, KIAA1978)

Function

• cooperates with PTBP1 to modulate regulated alternative splicing events
• promotes exon skipping
• cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of TPM1 pre-mRNA
• interacts with PTBP1, RAVER2, VCL & ACTN1
• component of a complex containing RAVER1, VCL & ACTN1

Structure

contains 3 RRM domains (RNA recognition motif)

Compartment

• nucleus, cytoplasm
• nuclear, in perinucleolar structures
• shuttles between nucleus & cytoplasm
• cytoplasm, at focal contacts & cell-cell contacts
• associated with myotubes during muscle differentiation

Alternative splicing

named isoforms=3

More general terms

• RNA-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8IY67.html