neurooncologic ventral antigen-2 (NOVA-2, astrocytic NOVA-1 like protein, ANOVA)

Function

• RNA splicing or metabolism
• binds single strand RNA.
• interacts with PTBP2

Compartment

nucleus

Expression

• mRNA expression restricted to astrocytes
• high levels seen in cerebral cortex, hippocampus & dorsal spinal cord
• gene maps to glioma tumor suppressor gene region on 19q13.3

Pathology

autoantigen paraneoplastic opsoclonus myoclonus ataxia (ANNA-2 (anti Ri Ab)

More general terms

• neurooncologic ventral antigen (NOVA)

Database

• OMIM: https://mirror.omim.org/entry/601991
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4858
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4858
• UniProt: http://www.uniprot.org/uniprot/Q9UNW9.html