RNA-binding protein Nova-1; neuro-oncological ventral antigen 1; onconeural ventral antigen 1; paraneoplastic Ri antigen; ventral neuron-specific protein 1 (NOVA1)

Function

• may regulate RNA splicing or metabolism in a specific subset of developing neurons
• interacts with PTBP2; the interaction is direct

Structure

• contains 3 KH domains

Compartment

• nucleus

Alternative splicing

• named isoforms=4

Expression

• expressed in developing motor system
• expression restricted to diencephalon, brainstem, motor neurons of ventral spinal cord

Pathology

• autoantigen in paraneoplastic opsoclonus myoclonus ataxia

More general terms

• neurooncologic ventral antigen (NOVA)
• nuclear protein
• phosphoprotein

Additional terms

• paraneoplastic opsoclonus myoclonus ataxia; Kinsbourne syndrome; myoclonic encephalopathy of infants; dancing eyes-dancing feet syndrome

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4857
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4857
• OMIM: https://mirror.omim.org/entry/602157
• UniProt: http://www.uniprot.org/uniprot/P51513.html