ATP-dependent RNA helicase DDX3Y; DEAD box protein 3, Y-chromosomal (DDX3Y, DBY)

Function

• probable ATP-dependent RNA helicase
• may play a role in spermatogenesi
• may interact with TDRD3

Structure

• belongs to the DEAD box helicase family, DDX3/DED1 subfamily
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain

Compartment

• cytoplasm, nucleus
• shuttles between the nucleus & cytoplasm ( XPO1-dependent)

Expression

• expression is testis-specific
• expressed predominantly in spermatogonia

Pathology

• DDX3Y is deleted in severe non-obstructive hypospermatogenesis

More general terms

• DEAD box ATP-dependent helicase
• phosphoprotein
• testis-specific protein
• Y chromosome protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8653
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8653
• OMIM: https://mirror.omim.org/entry/400010
• OMIM: https://mirror.omim.org/entry/400042
• UniProt: http://www.uniprot.org/uniprot/O15523.html