erg proto-oncogene protein; transcriptional regulator ERG; transforming protein ER (ERG)
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Function
- transcriptional regulator
- may participate in transcriptional regulation through recruitment of SETDB1 histone methyltransferase & subsequent modification of local chromatin structure
- interacts with SETDB1 (putative)
Structure
- belongs to the ETS family
- 98% homologous to fli-1 protein
- contains 1 ETS DNA-binding domain
- contains 1 PNT (pointed) domain
Compartment
Alternative splicing
named isoforms=6
Pathology
- chromosomal translocation t(21;22)(q22;q12) involving ERG with ERW is a cause of Erwing sarcoma
- chromosomal translocation t(16;21)(p11;q22) involving ERG with FUS is a cause of acute myeloid leukemia
More general terms
References
- ↑ Macleod K, Leprince D, Stehelin D. The ets gene family. Trends Biochem Sci. 1992 Jul;17(7):251-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1502727
- ↑ Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/ERGID53ch21q22.htm
- ↑ UniProt http://www.uniprot.org/uniprot/P11308.html