activating transcription factor-1; cyclic AMP-dependent transcription factor ATF-1; TREB36 protein (ATF1)
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Introduction
Forms heterodimer with CREB.
Function
- binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral & cellular promoters
- binds to the Tax-responsive element (TRE) of HTLV-I
- mediates PKA-induced stimulation of CRE-reporter genes
- binds DNA as a dimer
Structure
- belongs to the bZIP family, ATF subfamily
- contains 1 bZIP domain
- contains 1 KID (kinase-inducible) domain
Compartment
More general terms
References
- ↑ Hoeffler JP, Lustbader JW, Chen CY. Identification of multiple nuclear factors that interact with cyclic adenosine 3',5'-monophosphate response element-binding protein and activating transcription factor-2 by protein- protein interactions. Mol Endocrinol. 1991 Feb;5(2):256-66. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1828107
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=466
- ↑ Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/ATF1ID81.html
- ↑ UniProt http://www.uniprot.org/uniprot/P18846.html