kinesin-like 4 protein; kinesin-like DNA-binding protein; origin of plasmid DNA replication-binding protein; kinesin-like protein KIF22 (KNSL4, KIF22, KID, OBP)

Function

• involved in spindle formation & movements of chromosomes during mitosis & meiosis
• binds to microtubules & to DNA
• ubiquitinated, mediated by SIAH1 & leading to its subsequent proteasomal degradation (probable)
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the kinesin-like protein family
• contains 1 kinesin-motor domain

Compartment

• nucleus
• KNSL4 colocalizes with mitotic chromosomes
• enriched in the kinetochore at anaphase

More general terms

• kinesin family protein
• DNA-binding protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/603213
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3835
• UniProt: http://www.uniprot.org/uniprot/Q14807.html