DNA damage-inducible transcript 3; DDIT-3; growth arrest & DNA-damage-inducible protein GADD153; C/EBP-homologous protein; CHOP (DDIT3, CHOP, GADD153)

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Function

inhibits the DNA-binding activity of C/EBP & LAP by forming heterodimers that cannot bind DNA

Structure

belongs to the bZIP family
contains 1 bZIP domain

Compartment

Pathology

chromosomal translocation t(12;16)(q13;p11) involving DDIT3 with FUS is found in a form of malignant myxoid liposarcoma

More general terms

nuclear protein

References

↑ UniProt http://www.uniprot.org/uniprot/P35638.html
↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/DDIT3ID80.html
↑ NIEHS-SNPs http://egp.gs.washington.edu/data/ddit3/

Database

UniProt: http://www.uniprot.org/uniprot/P35638.html
Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1649
Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1649
OMIM: https://mirror.omim.org/entry/126337
OMIM: https://mirror.omim.org/entry/151900

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