zinc finger protein 346; just another zinc finger protein (ZNF346, JAZ)

Function

• binds to dsRNA & DNA (zinc-finger dependent)
• forms a heteromeric complex with XPO5 & ILF3
• found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 & double-stranded RNA
• interacts with XPO5
• interacts with ILF3 (RNA-independent)

Structure

• contains 4 matrin-type zinc fingers

Compartment

• nucleus, nucleolus, cytoplasm
• shuttles between the nucleus & cytoplasm when associated with XPO5

Alternative splicing

named isoforms=2

More general terms

• C2H2 type zinc finger protein

Database

• OMIM: https://mirror.omim.org/entry/605308
• UniProt: http://www.uniprot.org/uniprot/Q9UL40.html