protein phosphatase-1 regulatory subunit 9B (neurabin-2, spinophilin, PPP1R9B)

Function

• scaffold protein (putative)
• modulates excitatory synaptic transmission & dendritic spine morphology
• binds to actin filaments (F-actin) along sides
• links actin cytoskeleton to the plasma membrane at the synaptic junction (putative)
• G-protein coupled receptor signaling (putative)
  • dopamine D2 receptors
  • alpha-adrenergic receptors
• interacts with F-actin, PPP1CA, neurabin-1, TGN38, dopamine-D2-receptor, RGS1, RGS2, RGS4, RGS19, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CDKN2A, PPP1R2, RASGFR1, TIAM1

Compartment

• cytoplasm, nucleus
• enriched at synapse & cadherin-based cell-cell adhesion sites
• enriched in the post-synaptic density apposed to exitatory synapses
• colocalizes with PPP1R2 at actin-rich adherens junctions in epithelial cells & in dendritic spines

More general terms

• protein phosphatase-1 regulatory subunit

Database

• OMIM: https://mirror.omim.org/entry/603325
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84687
• UniProt: http://www.uniprot.org/uniprot/Q96SB3.html