regulator of G-protein signaling 4; RGP4 (RGS4)

Function

• inhibits signal transduction by increasing GTPase activity of G-alpha subunits thus increasing the amount of inactive GDP-bound form
• activity on Gz-alpha is inhibited by phosphorylation
• activity on Gz-alpha & Gi-alpha-1 is inhibited by palmitoylation (of G-protein)
• palmitoylated on Cys-2 &/or Cys-12
• phosphorylated by cyclic GMP-dependent protein kinase

Structure

contains 1 RGS domain

Pathology

• genetic variation in RGS4 is associated with susceptibility to schizophrenia type 9

More general terms

• regulator of G-protein signaling
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5999
• OMIM: https://mirror.omim.org/entry/181500
• OMIM: https://mirror.omim.org/entry/602516
• OMIM: https://mirror.omim.org/entry/604906
• UniProt: http://www.uniprot.org/uniprot/P49798.html