regulator of G-protein signaling 2; RGS2; G0/G1 switch regulatory protein 8; cell growth-inhibiting gene 31 protein (RGS2, G0S8, GIG31)

Function

• inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form
• may play a role in leukemogenesis
• phosphorylated by protein kinase C

Structure

contains 1 RGS domain

Expression

• expressed in acute myelogenous leukemia (AML) & in acute lymphoblastic leukemia (ALL)

More general terms

• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P41220.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5997
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5997
• OMIM: https://mirror.omim.org/entry/600861