rac2 proto-oncogene protein; EN7 protein; Ras-related C3 botulinum toxin substrate 2; p21-Rac2; small G protein; GX (RAC2)
Jump to navigation
Jump to search
Function
- plasma membrane-associated small GTPase
- cycles between an active GTP-bound & inactive GDP-bound state
- role in the regulation of neutrophil NADPH oxidase
- interacts with DOCK2, which may activate it
Structure
belongs to the small GTPase superfamily, Rho family
Compartment
- cytoplasm, membrane-associated when activated
Expression
hematopoietic specific
Pathology
- defects in RAC2 are the cause of neutrophil immunodeficiency syndrome [MIM:608203]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P15153.html
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/RAC2ID42021ch22q13.html
- ↑ RAC2base; Note: RAC2 mutation db http://bioinf.uta.fi/RAC2base/
- ↑ Kahn RA, Der CJ, Bokoch GM. The ras superfamily of GTP-binding proteins: guidelines on nomenclature. FASEB J. 1992 May;6(8):2512-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1592203
- ↑ Segal AW, Abo A. The biochemical basis of the NADPH oxidase of phagocytes. Trends Biochem Sci. 1993 Feb;18(2):43-7. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8488557
- ↑ Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature. 1994 Jan 6;367(6458):40-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8107774