liprin-alpha-4; protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4; PTPRF-interacting protein alpha-4 (PPFIA4 KIAA0897)

Function

• may regulate the disassembly of focal adhesions
• may localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment & their association with substrates
• forms homodimers & heterodimers with liprins-alpha & liprins-beta
• interacts with the second PTPase domain of PTPRD, PTPRF & PTPRS
• binds RIMS1, RIMS2, GIT1, KIF1A & GRIP1

Structure

• the N-terminal coiled coil regions mediate homodimerization preferentially & heterodimerization type alpha/alpha
• the C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta & interaction with PTPRD, PTPRF & PTPRS (putative)
• belongs to the liprin family, liprin-alpha subfamily
• contains 3 SAM (sterile alpha motif) domains

Compartment

• cytoplasm (putative). cell surface
• colocalizes with PTPRF at the cytoplasmic face of the plasma membrane

Alternative splicing

named isoforms=2

Expression

• expressed only in the heart, brain, & skeletal muscle

More general terms

• liprin-alpha

Additional terms

• receptor-type tyrosine-protein phosphatase F; Leukocyte common antigen related; LAR (PTPRF, LAR)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8497
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8497
• OMIM: https://mirror.omim.org/entry/603145
• UniProt: http://www.uniprot.org/uniprot/O75335.html