receptor-type tyrosine-protein phosphatase delta; protein-tyrosine phosphatase delta; R-PTP-delta (PTPRD)

Function

• tyrosine phosphatase
• undergoes 'ectodomain shedding'
• interacts with PPFIA1, PPFIA2 & PPFIA3

protein tyrosine phosphate + H2O = protein tyrosine + phosphate

Structure

• belongs to the protein-tyrosine phosphatase family receptor class 2A subfamily
• contains 8 fibronectin F3 modules
• contains 3 Ig-like C2-type domains
• contains 2 tyrosine-protein phosphatase domains

Compartment

• membrane; single-pass type 1 membrane protein

Alternative splicing

• named isoforms=3
• additional isoforms seem to exist
• at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense- mediated mRNA decay

More general terms

• tyrosine phosphatase, receptor type
• plasma membrane protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5789
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5789
• OMIM: https://mirror.omim.org/entry/601598
• UniProt: http://www.uniprot.org/uniprot/P23468.html